Cyclobenzaprine Tamucc Nurisng Pharmacology Cyclobenzaprine Flexeril: oral & extended

Cyclobenzaprine Tamucc Nurisng Pharmacology Cyclobenzaprine Flexeril: oral & extended

Note that this list is not all-inclusive and includes only common medications that may interact with Flexeril. You should refer to the prescribing information for Flexeril for a complete list of interactions. content is strictly informational and should not be considered medical advice. It is not recommended to consume alcohol while on Robaxin or Flexeril.

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Those with fibromyalgia may experience widespread muscle pain as well as problems with sleep, fatigue, and mood. According to a meta-analysis of five clinical trials, cyclobenzaprine was found to improve sleep and pain in patients with fibromyalgia over a period of up to 24 weeks. Robaxin or Flexeril are usually prescribed to treat musculoskeletal pain such as neck pain. Both drugs are also often used to treat low back pain, a common problem in adults in the US.

Dosage Modifications

If you experience these adverse effects, please seek emergency medical attention. Other medications can also act as centrally-acting muscle relaxants, such as benzodiazepines, but they’re most commonly used as anxiolytics, sedatives, or anticonvulsants. On the other hand, direct-acting muscle relaxants include dantrolene. Skeletal muscle relaxants are medications that reduce muscle contraction, so they are primarily used to relieve both acute or chronic muscle spasms and spasticity.

Centrally-acting muscle relaxants include cyclobenzaprine, methocarbamol, metaxalone, chlorzoxazone, tizanidine, baclofen, carisoprodol, and orphenadrine. When using the immediate-release tablets, consider less frequent dosing in patients with mild hepatic impairment; initiate with 5-mg dose and increase slowly. (See Hepatic Impairment under Cautions.) Use not recommended in patients with moderate or severe hepatic impairment. Flexeril is a brand name for cyclobenzaprine, a commonly prescribed muscle relaxant for muscle pain and other musculoskeletal conditions. Robaxin is the brand name of the generic medication called methocarbamol. It was developed in the 1960s to treat pain and provide relief from muscle spasms.

  • Skeletal muscle relaxants are prescription medications commonly used to treat muscle pain and muscle spasms.
  • This drug interaction can lead to serotonin syndrome, which can include symptoms like abnormally high fever, tremors, increased sweating, nausea, and vomiting.
  • Robaxin is the brand name of the generic medication called methocarbamol.
  • 15 mg once daily (at approximately the same time each day); some patients may require up to 30 mg once daily.
  • Flexeril is known to cause serotonin syndrome, especially when taken with certain antidepressants, MAO inhibitors, and opioids.

It is intended for general informational purposes and is not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911. Zanaflex has a half-life of around 2.5 hours while Flexeril has a half-life of 18 hours on average.

What are the possible drug interactions of cyclobenzaprine or methocarbamol?

Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepr[7]essants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical research, cyclobenzaprine reduced skeletal muscle hyperactivity. Research indicates that it primarily acts within the central nervous system in the brain stem.

These drugs can also help relieve muscle spasms and stiffness related to other physical conditions and injuries. Studies have compared cyclobenzaprine, methocarbamol, and other skeletal muscle relaxants and found that they are equally effective in treating acute musculoskeletal conditions. Cyclobenzaprine is one of the most studied skeletal muscle relaxants, with solid evidence and systematic reviews supporting its effectiveness. Both drugs are skeletal muscle relaxants or antispasmodic agents, but they contain different active ingredients.


Following administration, rinse mouth to ensure that all capsule contents have been swallowed. Administer orally (as immediate-release tablets or extended-release capsules). Alcohol may worsen the side effects of Flexeril such as drowsiness and dizziness.

The cyclobenzaprine high users may experience when taking dosages that exceed their prescription can result in feelings of sedation, relaxation or euphoria. These reactions can occur in individuals who either take the drug orally or snort it (ingest it intranasally). In patients with mild to moderate hepatic impairment, peak plasma concentration and AUC following administration of immediate-release tablets are twice the values in healthy individuals.

Spasticity is defined as a velocity-dependent increase in muscle tone that manifests with resistance to movement and involuntary muscle spasms and contractions. Common etiologies of spasticity include multiple sclerosis, stroke, tumor, cerebral palsy, and spinal or peripheral nerve injury. Nerve conduction studies and imaging what does flexeril do for you of the brain and/or spinal cord may be requested to determine the underlying etiology. Zanaflex (tizanidine) and Flexeril (cyclobenzaprine) are muscle relaxants used to treat painful musculoskeletal conditions. If you experience neck or back strains, you may be recommended a muscle relaxant like Zanaflex or Flexeril.

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